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Предложено решение проблемы опухолеобразования при регенеративной терапии стволовыми клетками

Timon, 02.11.2012 14:40
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Индуцированные плюрипотентные стволовые клетки (иПСК) обладают неограниченной способностью дифференцироваться в любой тип ткани. Эта способность иПСК открывает перед регенеративной медициной огромные возможности: повреждённые или больные ткани можно вылечить или заменить новой растущей тканью.

Однако у этого способа есть существенная проблема, которая сдерживает развитие терапевтического использования иПСК. После того, как иПСК снова дифференцируются в желаемую ткань, среди них могут оставаться недифференцированные клетки. Они могут начать бесконтрольно активно делиться, что приведёт к образованию опухоли.

Исследователи из Клиники «Мэйо» (Mayo Clinic) в США предложили возможное решение: в статье, опубликованной в журнале Stem Cells Translational Medicine от 27 сентября, они представили эксперименты по селективному уничтожению опухолеобразующих клеток путём повреждения их ДНК.

В этом исследовании старший автор Timothy Nelson и его коллеги на лабораторных мышах показали, что препараты химиотерапии выборочно повреждают ДНК стволовых клеток, запуская клеточное самоубийство (апоптоз). Соматические клетки при этом не страдают, потому что они менее чувствительны к такому воздействию.

Группа считает, что это поможет убрать барьер использования иПСК в регенеративной терапии, сделав её безопасной, но такой же эффективной.


Alyson J. Smith, Natalie G. Nelson, Saji Oommen, Katherine A. Hartjes, Clifford D. Folmes, Andre Terzic, Timothy J. Nelson Apoptotic Susceptibility to DNA Damage of Pluripotent Stem Cells Facilitates Pharmacologic Purging of Teratoma Risk, Stem Cells Trans Med first published on September 27, 2012
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