В скором времени криоэлектроннaя микроскопия, по-видимому, потеснит господствующий ныне метод рентгеноструктурного анализа, позволяющий определять структуры белков de novo.

Ученые из центра Кека в Сан-Франциско продемонстрировали потенциал новых детекторов электронов, определив структуру ионного канала TRPV1 – рецептора температуры и боли в нейронах и соматических клетках, - кристаллизация которого была затруднительной и нереализованной. Работа оказалась столь значимой, что ее результаты опубликованны сразу в двух статьях, описывающих сам метод, разные конформации TRPV1, и связывание TRPV1 с лигандами (в том числе - с капсаицином, компонентом перца чили, вызывающим чувство острого жжения), позволяя понять общие принципы восприятия температуры и боли.

На электронных картах видны не только очертания молекулы и элементы вторичной структуры, но и боковые группы аминокислот – впервые в истории метода после того, как подобное качество карт было достигнуто для высокосимметричных вирусных частиц! Эти инновации обещают колоссальное упрощение определения структуры биологических молекул, клеток и тканей, хотя при высокой дороговизне микроскопов и детекторов метод будет доступен далеко не каждому.

Рисунок: усредненные проекции белка и экспериментальная электронная плотность, позволяющая определить структуру вплоть до положения боковых цепей аминокислот.

Работы:
Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Liao M, Cao E, Julius D, Cheng Y. Nature. 2013 Dec 5
TRPV1 structures in distinct conformations reveal activation mechanisms. Cao E, Liao M, Cheng Y, Julius D. Nature. 2013 Dec 5

Спасибо за такие новости!

Такие хорошие или такие плохие новости?

Интересные!

Мы будем стараться и в следующем году, спасибо за Ваши комментарии, они делают новости интереснее!

Нужен аналогичный метод, который бы показал и кинетику изменения структуры.

Что интересного? Картинки страшненькие и серенькие.

Каким образом можно показать кинетику изменения структуры, поподробнее расскажите, интересно прочитать ваше мнение.

Это - не картинки

это уже кино

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