, lncRNA-ATB TGF-β lncRNA. lncRNA-ATB , . (hepatocellular carcinoma HCC) . . - (EMT), - (TGF-β). TGF-β , TGF-β, TGF-β HCC. , ( 200 ) , TGF-β EMT .
SMMC-7721 TGF-β EMT, , . 297 676 lncRNA (activated by TGF-β - lncRNA-ATB). TGF-β lncRNA-ATB , , . LncRNA-ATB , .
46 lncRNA-ATB 76 , miR-200. , miR-200 3'-UTR ZEB1 ZEB2. , miR-200 lncRNA-ATB, . lncRNA-ATB miR-200 ZEB1 ZEB2. miR-200 . 86 ZEB1 ZEB2 lncRNA-ATB. lncRNA-ATB 86 .
, in vivo lncRNA-ATB ZEB1 ZEB2, . miR-200. LncRNA-ATB , miR-200. .
, lncRNA . lncRNA-ATB , -11 (IL-11). , IL-11 STAT3 . , lncRNA-ATB IL-11, STAT3 . miR-200. , IL-11 . , IL-11 lncRNA-ATB IL-11. LncRNA-ATB , IL-11.
: Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, Wang SB, Wang YZ, Yang Y, Yang N, Zhou WP, Yang GS, Sun SH. // Cancer Cell. 2014; V. 25: P. 666-681.
: LncRNA-ATB, TGF-β, miR-200, ZEB1 ZEB2, . , lncRNA-ATB -11, IL-11 STAT3.
