- (cancer-propagating cells (CPCs)) . CPCs. , CPCs, . (hematopoietic stem cell (HSC)). , HSC, - (leukemia-propagating cells (LPCs)). , . . , , .
(acute lymphoblastic leukemia (ALL)) . ALL ALL . ALL ( / ) ALL , , . , , . ( CCL3), , . Nestin+ α-SMA+.
ALL . , ( 32 ) GDF15. GDF15 (Growth differentiation factor 15) . ALL GDF15 . GDF15, , ALL , . GDF15, ALL , Smad3, TGF-β. ALL GDF15, TGF-β .
, , ALL, 7 . 5 . , . , LPCs. , , LPCs, ALL.
50 ALL , , 30 , 15 , 5 . 15 20 . 5 20 , , . 30 , . GDF15 BCL-2. , .
: Duan CW, Shi J, Chen J, Wang B, Yu YH, Qin X, Zhou XC, Cai YJ, Li ZQ, Zhang F, Yin MZ, Tao Y, Mi JQ, Li LH, Enver T, Chen GQ, Hong DL.
: .
SV , LPCs - leukemia-propagating cells, MSCs .