Õîðîøî èçâåñòíî, ÷òî â îïóõîëåâûõ êëåòêàõ ïðîèñõîäèò èçìåíåíèå ìåòèëèðîâàíèÿ ÄÍÊ è ïîñòòðàíñëÿöèîííîé ìîäèôèêàöèè ãèñòîíîâ - ÷òî ïðèâîäèò ê ìîäèôèêàöèè ñòðóêòóðû õðîìàòèíà è èçìåíåíèþ ïàòòåðíà ýêñïðåññèè ðàçëè÷íûõ ãåíîâ.  ñâÿçè ñ ýòèì «ýïèãåíåòè÷åñêèé ëàíäøàôò» îïóõîëåâîé êëåòêè èãðàåò âàæíóþ ðîëü â îïðåäåëåíèè åå ñóäüáû è âîçìîæíîñòè ëå÷åíèÿ ðàêà. Îäíàêî ïîêà îá ýòîì èçìåíåíèè ñòðóêòóðû ýïèãåíîìà â îïóõîëåâîé êëåòêå èçâåñòíî î÷åíü ìàëî. Îäèí èç âàæíûõ ìåõàíèçìîâ ðåãóëÿöèè ñòðóêòóðû õðîìàòèíà - àöåòèëèðîâàíèå è äåàöåòèëèðîâàíèå ãèñòîíîâ.  íàñòîÿùåé ðàáîòå àâòîðàìè èç Èñïàíèè è ðÿäà äðóãèõ ñòðàí Åâðîïû ïîêàçàí îäèí èç âîçìîæíûõ ïóòåé íàðóøåíèÿ ñòðóêòóðû õðîìàòèíà â îïóõîëåâûõ êëåòêàõ - ÷åðåç èíàêòèâèðóþùèå ìóòàöèè â ãåíå äåàöåòèëàçû ãèñòîíîâ HDAC2. Ýòè ìóòàöèè ñâÿçàíû ñ èçìåíåíèåì ðàçìåðà ïîëèàäåíèíîâîãî áëîêà òèï À9 â ïåðâîì ýêçîíå ãåíà è ïðèâîäÿò ê ñäâèãó ðàìêè ñ÷èòûâàíèÿ è ïîëíîìó íàðóøåíèþ ñèíòåçà HDAC2 â îïóõîëåâûõ êëåòêàõ. Îíè îáíàðóæåíû êàê â êóëüòèâèðóåìûõ îïóõîëåâûõ êëåòêàõ, òàê è â 21% ïåðâè÷íûõ îïóõîëåé òîëñòîãî êèøå÷íèêà, æåëóäêà è ýíäîìåòðèÿ. Ñêîðåå âñåãî, ýòè ìóòàöèè íå ÿâëÿþòñÿ ïåðâîïðè÷èíîé ðàçâèòèÿ ðàêà - à ÿâëÿþòñÿ ñîïóòñòâóþùèì îïóõîëåâîìó ðîñòó ñîáûòèåì è õàðàêòåðíû äëÿ ðàêà ñ ïîâûøåííîé íåñòàáèëüíîñòüþ ìèêðîñàòåëëèòîâ. Èíàêòèâàöèÿ ãåíà HDAC2 â îïóõîëåâûõ êëåòêàõ ïðèâîäèò ê òîìó, ÷òî îíè ñòàíîâÿòñÿ ìåíåå ÷óâñòâèòåëüíû ê äåéñòâèþ èíãèáèòîðîâ äåàöåòèëàç ãèñòîíîâ, â ÷àñòíîñòè ïðåïàðàòîâ èç ãðóïïû òðèõîñòàòèíà À. Ýòî ñíèæàåò ôàðìàêîëîãè÷åñêóþ ýôôåêòèâíîñòü ïðåïàðàòîâ ýòîé ãðóïïû è àíàëèç ìóòàöèé â áëîêå À9 ãåíà HDAC2 ìîæåò áûòü ðåêîìåíäîâàí äëÿ âûáîðà ñòðàòåãèè ëå÷åíèÿ ïðè îïóõîëÿõ ñ íåñòàáèëüíîñòüþ ìèêðîñàòåëëèòîâ.
(Ropero S. et al A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nature Genetics. Published online: 16 April 2006; |ng1773)
êàòåãîðèÿ - 2
 
| |
[ Âõîä | Ðåãèñòðàöèÿ ]
|
Äåàöåòèëàçà ãèñòîíîâ è ðàê ó ÷åëîâåêà
Lady, 26.04.2006 08:05
vrida2, 30.01.2022 03:58
vrida2, 15.04.2022 16:32
nigoal123, 28.04.2022 11:48
An article is written on a particular theme in a style that makes it suitable for publication in an English-language newspaper, magazine
Always read the instructions for. the task carefully to be clear about on things, so most whom you are writing for.
Always read the instructions for. the task carefully to be clear about on things, so most whom you are writing for.
nigoal123, 29.04.2022 10:44
Article writing is a staple for every business seeking to stand out great process until completion. writer to be successful. from the crowd.
That’s why you need high-quality articles to showcase your expertise fuel your social media and contribute to your SEO rankings.
That’s why you need high-quality articles to showcase your expertise fuel your social media and contribute to your SEO rankings.
nigoal123, 30.04.2022 11:22
You need an idea something you want to share together an outline to show us that your idea is likely to be of interest to our readers. From that point on
we can give you any help that you need as you write and revise your article. Experienced writers all started somewhere your writing career with us.
we can give you any help that you need as you write and revise your article. Experienced writers all started somewhere your writing career with us.
vrida2, 25.07.2022 08:34
fashionicon, 25.07.2022 11:22
vrida2, 23.10.2022 22:33
watchesonline89, 04.12.2022 12:10
vrida2, 21.12.2022 02:26
vrida2, 12.01.2024 23:21
Ýòî — ë¸ãêàÿ âåðñèÿ ôîðóìà. ×òîáû ïîïàñòü íà ïîëíóþ, ùåëêíèòå çäåñü.